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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: THOC2 All Species: 42.42
Human Site: Y521 Identified Species: 71.79
UniProt: Q8NI27 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8NI27 NP_001075019.1 1593 182775 Y521 T F P Y Q H R Y R L Y G Q W K
Chimpanzee Pan troglodytes XP_001139291 1595 183045 Y523 T F P Y Q H R Y R L Y G Q W K
Rhesus Macaque Macaca mulatta XP_001086217 1593 182783 Y521 T F P Y Q H R Y R L Y G Q W K
Dog Lupus familis XP_538164 1593 182721 Y521 T F P Y Q H R Y R L Y G Q W K
Cat Felis silvestris
Mouse Mus musculus B1AZI6 1594 182755 Y521 T F P Y Q H R Y R L Y G Q W K
Rat Rattus norvegicus XP_233081 1594 182711 Y521 T F P Y Q H R Y R L Y G Q W K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510761 1648 188085 Y572 T F P Y Q Y R Y R L Y G Q W K
Chicken Gallus gallus XP_420332 1593 182430 Y518 T F P Y Q Y R Y R L Y G Q W K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001003847 1504 172218 Y502 F F P Y Q H R Y R L Y G Q W K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_722763 1641 188490 Y582 Y F P Y H F R Y S L Y A R W K
Honey Bee Apis mellifera XP_393587 1354 156054 L409 L E E L H D Q L L P M L I V L
Nematode Worm Caenorhab. elegans NP_498392 1437 164369 T444 I K I V R L L T A Y Y R K V D
Sea Urchin Strong. purpuratus XP_795489 1592 178912 Y516 M L P Y H R R Y C L Y A R W I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_173871 1804 205705 R540 S L L P Y E A R Y R L Y G E W
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 99.9 99 N.A. 97.4 97.4 N.A. 85.8 88.1 N.A. 72.9 N.A. 39.7 43.1 29.5 48.7
Protein Similarity: 100 99.3 100 99.3 N.A. 98.9 99 N.A. 91.4 93.9 N.A. 83.4 N.A. 59 60.2 48.5 65.1
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 93.3 N.A. 93.3 N.A. 60 0 6.6 46.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 N.A. 93.3 N.A. 66.6 6.6 20 53.3
Percent
Protein Identity: N.A. N.A. N.A. 31.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 48.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 8 0 8 0 0 15 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % D
% Glu: 0 8 8 0 0 8 0 0 0 0 0 0 0 8 0 % E
% Phe: 8 72 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 65 8 0 0 % G
% His: 0 0 0 0 22 50 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 8 0 0 0 0 0 0 0 0 0 8 0 8 % I
% Lys: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 72 % K
% Leu: 8 15 8 8 0 8 8 8 8 79 8 8 0 0 8 % L
% Met: 8 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 79 8 0 0 0 0 0 8 0 0 0 0 0 % P
% Gln: 0 0 0 0 65 0 8 0 0 0 0 0 65 0 0 % Q
% Arg: 0 0 0 0 8 8 79 8 65 8 0 8 15 0 0 % R
% Ser: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % S
% Thr: 58 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % T
% Val: 0 0 0 8 0 0 0 0 0 0 0 0 0 15 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 79 8 % W
% Tyr: 8 0 0 79 8 15 0 79 8 8 86 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _